Homozygous State for Hb Constant Spring (Slow-moving Hb X Components)

Homozygous state for Hb Constant Spring (slow-moving Hb X components).

Molecular characterization of thalassemia intermedia with homozygous Hb Malay and Hb Malay/HbE in Thai patients.

Patients with thalassemia intermedia have a mild anemia and survive without needing regular blood transfusions.1 Here we report two cases of Thai patients with β-thalassemia intermedia caused by homozygosity of hemoglobin Malay (Hb Malay; α2β219Asn-Ser)2 and compound heterozygosity of Hb Malay and hemoglobin E (Hb E; α2β226Glu-Lys). Both patients presented with a history of anemia with marked m...

Severe hemolytic anemia associated with the homozygous state for an unstable hemoglobin variant (Hb Bushwick).

We have investigated a 13-year-old girl from first cousin parents who presented with severe hemolytic anemia. Hematologic studies showed unstable hemoglobin (Hb) disease (chronic Heinz body anemia), and DNA analysis showed that the patient was homozygous for the previously reported abnormal Hb called Hb Bushwick (beta 74E18 gly-->val). Hb Bushwick is unstable in vitro and in vivo. In addition, ...

Practical Attacks on HB and HB+ Protocols

HB and HB+ are a shared secret-key authentication protocols designed for low-cost devices such as RFID tags. HB+ was proposed by Juels and Weis at Crypto 2005. The security of the protocols relies on the learning parity with noise (LPN) problem, which was proven to be NP-hard. The best known attack on LPN by Levieil and Fouque [13] requires subexponential number of samples and sub-exponential n...

Secondary polycythaemia in a Malay girl with homozygous Hb Tak.

Hb Tak is one of more than 200 high affinity haemoglobin variants reported worldwide. It results from the insertion of two nucleotides (AC) at the termination codon, between codon 146 and codon 147 of the beta-globin gene [Beta 147 (+AC)]. Polycythaemia is the main clinical feature although affected carriers are usually asymptomatic and do not require intervention. Several case studies in this ...